Dr. Alex Upfill-Brown, Spine Surgeon, Headshot

Dr. Alex Upfill-Brown

Spine Surgeon

WHY I BECAME A SPINE SURGEON

I always knew I wanted to make a difference in people’s lives. Without a family legacy in medicine, I charted my own path to orthopedic spine surgery. My desire to dedicate years of education, training, and sacrifice was driven by the challenge of complex spine care. I take pride in listening and learning from my patients so that I can provide personalized solutions others may not have offered. Being able to give someone a chance to get back to the life they’ve been missing is what makes that challenge so rewarding!

Dr. Alex Upfill-Brown is a spine surgeon at VSI with a decade of experience treating the full spectrum of spine conditions, supported by a unique foundation in spine care. While his expertise spans advanced, minimally invasive surgical and non-surgical techniques for patients of all needs, he has a distinct niche in caring for patients with complex spinal deformities, such as adolescent scoliosis, adult scoliosis, and kyphosis.

Dr. Upfill-Brown’s Surgical Experience

Dr. Upfill-Brown completed his spine surgery fellowship at the prestigious Hospital for Special Surgery (HSS) in New York, regarded as one of the premier orthopedic institutions in the world, following an orthopedic surgery residency at UCLA, where he was elected to serve as Executive Co-Chief Resident during his tenure.

His surgical expertise is grounded in a rare depth of technical training. As a postdoctoral fellow in UCLA’s Department of Mechanical and Aerospace Engineering, he designed and tested novel motion-preserving joint replacement devices – a background that has made him an advocate for artificial disc replacement. He further expanded his surgical expertise through an advanced fellowship in minimally invasive endoscopic surgery techniques in Korea, along with international training in scoliosis and kyphosis. Combined with his broader surgical background, Dr. Upfill-Brown’s specialized training gives him the range to treat even the most complex spinal conditions and personalize the approach for each patient.

A Unique Approach to Patient Care

Dr. Upfill-Brown treats each patient like a close family member, taking the time necessary to listen fully and understand their history before recommending a path forward. He works hand-in-hand with his patients to create ultra-customized treatment plans to achieve their recovery goals. The solutions include non-surgical therapies, injections, natural healing options, and when necessary, minimally invasive surgical procedures.

With roots in South Africa, Dr. Upfill-Brown has worked in global health in Nigeria, Pakistan, and Bangladesh. Those firsthand experiences shaped the perspective in which he approaches healthcare. His education and training further drew him toward spine surgery, where he found purpose in solving complex conditions and providing care that changes lives.

What to Expect Under Dr. Upfill-Brown’s Care

Under Dr. Upfill-Brown’s care at VSI, patients benefit from seamless collaboration with an in-house interdisciplinary team comprised of physiatrists, a neurologist, spine-specialized physical therapists, massage therapists, and pain specialists, all prioritizing motion preservation and rapid recovery. Dr. Upfill-Brown is also a national researcher with 68 peer-reviewed publications spanning topics such as minimally invasive techniques, artificial disc replacement, and spinal deformity, to pioneer ways to make surgeries safer and more effective for patients.

College

  • Stanford University

Graduate Studies

University of Oxford — MSc in Sociology

Medical School

  • University of California, Los Angeles, David Geffen School of Medicine 

Residency

  • Orthopedic Surgery, University of California, Los Angeles School of Medicine 

Fellowship

  • Spine Surgery, Hospital for Special Surgery (New York)

Affiliations

  • HCA Healthcare

Spine Conditions Treated by Dr. Upfill-Brown

Dr. Upfill-Brown is an orthopedic spine surgeon who treats a diverse range of spinal conditions, including, but not limited to:

Minimally Invasive Treatment Solutions

Dr. Upfill-Brown provides patients with innovative, advanced non-surgical and surgical solutions that are not offered elsewhere in the Mid-Atlantic region.

Dr. Upfill-Brown’s Highlights

  • American Orthopaedic Association Emerging Leader Program (2024)
  • Executive Co-Chief Resident, UCLA Department of Orthopaedic Surgery (2024–2025)
  • NIH T32 Regenerative Musculoskeletal Medicine Training Grant (2021–2024)
  • Co-Founder, FleX Orthopaedics, Inc. — commercializing novel compliant orthopedic implants (2022)
    • Named inventor on U.S. patent for compliant orthopedic joint replacement mechanisms
  • H&H Lee Surgical Scholars Research Grant (2021-2022)
  • Alpha Omega Alpha Honor Medical Society (2018)
  • David Geffen Scholarship — merit-based full-tuition scholarship, UCLA School of Medicine (2015-2019)
  • A.H. Halsey Prize for Best MSc Dissertation, University of Oxford (2012)
  • Author or co-author of 68 peer-reviewed publications and more than 40 national podium/poster presentations in spine and orthopedic surgery

Dr. Upfill-Brown’s Recent Research


A Machine Learning-Driven Model Predicts Patient-Reported Dysphagia After Instrumented Cervical Fusion

Artificial Intelligence in Surgery (2025)


The Evaluation, Prevention, and Management of Proximal Junctional Kyphosis and Failure

Journal of the American Academy of Orthopaedic Surgeons (2025)


Endoscopic Posterior Cervical Foraminotomy Techniques and Outcomes

Seminars in Spine Surgery (2024)


Clinical Outcomes and Complications After Biportal Endoscopic Spine Surgery: A Comprehensive Systematic Review and Meta-Analysis of 3,673 Cases

European Spine Journal (2023)


Biportal Endoscopic Approach for Lumbar Degenerative Disease in the Ambulatory Outpatient vs Inpatient Setting: A Comparative Study

International Journal of Spine Surgery (2023)


Identification of Novel Patient Factors for Implant-Related Complications After Instrumented Spinal Fusion: A Machine Learning-Driven Approach

World Neurosurgery (2022)


National Trends in the Utilization of Lumbar Disc Replacement for Lumbar Degenerative Disc Disease Over a 10-Year Period, 2010 to 2019

Journal of Spine Surgery (2022)


Utilization Trends and Outcomes of Computer-Assisted Navigation in Spine Fusion

The Spine Journal (2021)

Dr. Upfill-Brown has authored or co-authored nearly 70 research publications. To view more, visit PubMed® and search “Alexander Upfill-Brown”.

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